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Quelle GmbH
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Image Search Results
Journal: Haematologica
Article Title: Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells
doi: 10.3324/haematol.2019.230227
Figure Lengend Snippet: iPAI-1 protects chronic myeloid leukemia cells from tyrosine kinase inhibitor treatment. (A) A representative flow cytometric profile for intracellular plasminogen activator inhibitor-1 (iPAI-1) expressions in PAI-1-overexpression (PAI-1 OE), PAI-1-knockdown (PAI-1 KD), or wild-type parental 32D p210 cells (PAI-1 WT). (B) Representative flow cytometric profiles and percentage of Annexin V + /PI + population in PAI-1 OE, PAI-1 KD, or PAI-1 WT cells before imatinib (Pre-IM) and after imatinib (Post-IM) treatment in vitro (n=6). (C) Schema for in vivo experiments. (D) Representative flow cytometric profiles and percentages of leukemic cells in the bone marrow (BM) (n=7). Data represent means ± standard deviation. Statistical significance was determined by Mann-Whitney unpaired t -test. P <0.001, by a Kruskal-Wallis test. GFP: green fluorescent protein.
Article Snippet: Another set of experiments, gene-modified
Techniques: Over Expression, In Vitro, In Vivo, Standard Deviation, MANN-WHITNEY